Nonstop flights from Houston to Louisville
Southwest Airlines flies this route daily.
HOUHouston William P. Hobby
803 mi · 7 flights a week
SDFLouisville Muhammad Ali International
When they leave
Houston time11:00a3:25pFirst departure 11:00 AM, last 3:25 PM
One morning flight at 11:00 AM, then three in the afternoon, 12:25 PM to 3:25 PM.
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Earliest first
Schedules last checked Sep 21, 2026. Times are local.
Flying from Houston to Louisville
Southwest Airlines is the only airline flying nonstop from Houston to Louisville, daily on the Boeing 737 MAX 8 and Boeing 737-700.
The first arrival in Louisville is at 2:15 PM and the last at 6:35 PM. The flight covers 803 miles.
Flying back, Louisville to Houston has 7 nonstop flights a week. George Bush Intercontinental (IAH) also has nonstop flights to Louisville, 21 a week.
Return flights
Every Houston airport
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Find the cheapest day to fly from Houston to Louisville.
Schedules as of Oct 9, 2026.