Nonstop flights from Louisville to Houston
Southwest Airlines flies this route daily.
SDFLouisville Muhammad Ali International
803 mi · 7 flights a week
HOUHouston William P. Hobby
When they leave
Louisville time12:40p6:25pFirst departure 12:40 PM, last 6:25 PM
Three in the afternoon, 12:40 PM to 1:45 PM, then one evening flight at 6:25 PM.
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Earliest first
Schedules last checked Sep 19, 2026. Times are local.
Flying from Louisville to Houston
Southwest Airlines is the only airline flying nonstop from Louisville to Houston, daily on the Boeing 737-700, Boeing 737 and Boeing 737 MAX 8.
The first arrival in Houston is at 1:55 PM and the last at 7:40 PM. The flight covers 803 miles.
Flying back, Houston to Louisville has 7 nonstop flights a week. From Louisville, George Bush Intercontinental (IAH) is the other Houston area airport with nonstop flights, 21 a week.
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Schedules as of Oct 9, 2026.