Nonstop flights from Louisville to Detroit
Delta Air Lines flies this route 3 to 4 times a day.
SDFLouisville Muhammad Ali International
305 mi · 27 flights a week
DTWDetroit Metropolitan Wayne County
When they leave
Louisville time7:55a5:25pFirst departure 7:55 AM, last 5:25 PM
Two in the morning, 7:55 AM to 10:34 AM, then one afternoon flight at 2:34 PM, then one evening flight at 5:25 PM.
Every flight
Earliest first
Schedules last checked Sep 21, 2026. Times are local.
Flying from Louisville to Detroit
Delta Air Lines is the only airline flying nonstop from Louisville to Detroit, 3 to 4 times a day on the CRJ 900 and Embraer 175.
There are 3 or 4 flights every day of the week. The first arrival in Detroit is at 9:21 AM and the last at 6:58 PM. The flight covers 305 miles.
Flying back, Detroit to Louisville has 27 nonstop flights a week.
Return flights
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Find the cheapest day to fly from Louisville to Detroit.
Schedules as of Oct 9, 2026.