Nonstop flights from Detroit to Louisville
Delta Air Lines flies this route 3 to 4 times a day.
DTWDetroit Metropolitan Wayne County
305 mi · 27 flights a week
SDFLouisville Muhammad Ali International
When they leave
Detroit time8:25a7:52pFirst departure 8:25 AM, last 7:52 PM
One morning flight at 8:25 AM, then two in the afternoon, 12:25 PM to 3:54 PM, then one evening flight at 7:52 PM.
Every flight
Earliest first
Schedules last checked Sep 19, 2026. Times are local.
Flying from Detroit to Louisville
Delta Air Lines is the only airline flying nonstop from Detroit to Louisville, 3 to 4 times a day on the CRJ 900, CRJ 700 and Embraer 175.
There are 3 or 4 flights every day of the week. The first arrival in Louisville is at 9:54 AM and the last at 9:19 PM. The flight covers 305 miles.
Flying back, Louisville to Detroit has 27 nonstop flights a week.
Return flights
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Find the cheapest day to fly from Detroit to Louisville.
Schedules as of Oct 9, 2026.