Nonstop flights from Chicago to Des Moines

2 airlines fly this route, with up to 9 flights a day.

ORDChicago O'Hare International

298 mi · 63 flights a week

DSMDes Moines International

ORDDSM

When they leave

Chicago time

8:26a10:45pFirst departure 8:26 AM, last 10:45 PM

Four in the morning, 8:26 AM to 11:54 AM, then two in the afternoon, 12:50 PM to 4:00 PM, then three in the evening, 5:46 PM to 10:45 PM.

Every flight

Earliest first

8:26 AM→9:56 AMAmerican AirlinesEmbraer 170Daily
9:00 AM→10:26 AMUnited AirlinesAirbus A319Daily
10:45 AM→12:20 PMUnited AirlinesEmbraer 175Mon, Tue, Wed, Thu, Fri, Sun
10:45 AM→12:18 PMUnited AirlinesCRJ 700Sat
11:54 AM→1:25 PMAmerican AirlinesCRJ 700Daily
12:50 PM→2:14 PMUnited AirlinesBoeing 737Daily
4:00 PM→5:28 PMUnited AirlinesAirbus A319Daily
5:46 PM→7:19 PMAmerican AirlinesCRJ 700Daily
7:55 PM→9:23 PMUnited AirlinesAirbus A319Daily
10:45 PM→12:20 AM⁺¹American AirlinesEmbraer 175Daily

Schedules last checked Sep 19, 2026. Times are local.

Flying from Chicago to Des Moines

United Airlines flies most often, 5 times a day on the Airbus A319, Boeing 737, CRJ 700 and Embraer 175. American Airlines flies 4 times a day on the CRJ 700, Embraer 170 and Embraer 175.

There are 9 flights every day of the week. The first arrival in Des Moines is at 9:56 AM and the last at 12:20 AM the next day. The flight covers 298 miles.

Flying back, Des Moines to Chicago has 58 nonstop flights a week. Midway (MDW) also has nonstop flights to Des Moines, 12 a week.