Nonstop flights from Chicago to Des Moines

Southwest Airlines flies this route 12 times a week.

MDWChicago Midway International

305 mi · 12 flights a week

DSMDes Moines International

MDWDSM

When they leave

Chicago time

10:05a8:50pFirst departure 10:05 AM, last 8:50 PM

Three in the morning, 10:05 AM to 10:15 AM, then two in the evening, 8:35 PM to 8:50 PM.

Every flight

Earliest first

10:05 AM→11:25 AMSouthwest AirlinesBoeing 737 MAX 8Mon, Tue, Wed, Fri
10:10 AM→11:30 AMSouthwest AirlinesBoeing 737 MAX 8Sat
10:15 AM→11:35 AMSouthwest AirlinesBoeing 737-700Sun
8:35 PM→9:55 PMSouthwest AirlinesBoeing 737-700Tue, Wed, Sat, Sun
8:50 PM→10:10 PMSouthwest AirlinesBoeing 737-700Mon, Fri

Schedules last checked Sep 19, 2026. Times are local.

Flying from Chicago to Des Moines

Southwest Airlines is the only airline flying nonstop from Chicago to Des Moines, 12 times a week on the Boeing 737-700 and Boeing 737 MAX 8.

Flights run every day except Thursdays, up to 2 a day. The first arrival in Des Moines is at 11:25 AM and the last at 10:10 PM. The flight covers 305 miles.

Flying back, Des Moines to Chicago has 14 nonstop flights a week. O'Hare (ORD) also has nonstop flights to Des Moines, 63 a week.

Return flights

Des Moines to ChicagoView

Every Chicago airport

All Chicago to Des Moines flightsView

Find the cheapest day to fly from Chicago to Des Moines.

Schedules as of Oct 9, 2026.