Nonstop flights from Chicago to Des Moines

3 airlines fly from 2 Chicago airports (ORD and MDW) to Des Moines (DSM), with up to 11 flights a day.

ORDDSM

Routes

2 airport pairs

When they leave

Chicago time

8:26a10:45pFirst departure 8:26 AM, last 10:45 PM

Seven in the morning, 8:26 AM to 11:54 AM, then two in the afternoon, 12:50 PM to 4:00 PM, then five in the evening, 5:46 PM to 10:45 PM.

Every flight

Earliest first

8:26 AM→9:56 AMORD to DSMAmerican AirlinesEmbraer 170Daily
9:00 AM→10:26 AMORD to DSMUnited AirlinesAirbus A319Daily
10:05 AM→11:25 AMMDW to DSMSouthwest AirlinesBoeing 737 MAX 8Mon, Tue, Wed, Fri
10:10 AM→11:30 AMMDW to DSMSouthwest AirlinesBoeing 737 MAX 8Sat
10:15 AM→11:35 AMMDW to DSMSouthwest AirlinesBoeing 737-700Sun
10:45 AM→12:20 PMORD to DSMUnited AirlinesEmbraer 175Mon, Tue, Wed, Thu, Fri, Sun
10:45 AM→12:18 PMORD to DSMUnited AirlinesCRJ 700Sat
11:54 AM→1:25 PMORD to DSMAmerican AirlinesCRJ 700Daily
12:50 PM→2:14 PMORD to DSMUnited AirlinesBoeing 737Daily
4:00 PM→5:28 PMORD to DSMUnited AirlinesAirbus A319Daily
5:46 PM→7:19 PMORD to DSMAmerican AirlinesCRJ 700Daily
7:55 PM→9:23 PMORD to DSMUnited AirlinesAirbus A319Daily
8:35 PM→9:55 PMMDW to DSMSouthwest AirlinesBoeing 737-700Tue, Wed, Sat, Sun
8:50 PM→10:10 PMMDW to DSMSouthwest AirlinesBoeing 737-700Mon, Fri
10:45 PM→12:20 AM⁺¹ORD to DSMAmerican AirlinesEmbraer 175Daily

Schedules last checked Sep 19, 2026. Times are local.

Flying from Chicago to Des Moines

United Airlines flies most often, 5 times a day on the Airbus A319, Boeing 737, CRJ 700 and Embraer 175. American Airlines flies 4 times a day on the CRJ 700, Embraer 170 and Embraer 175. Southwest Airlines flies 12 times a week on the Boeing 737-700 and Boeing 737 MAX 8.

Flights run every day of the week, from 9 on Thursdays to 11 on Mondays, Tuesdays, Wednesdays, Fridays, Saturdays and Sundays. The first arrival in Des Moines is at 9:56 AM and the last at 12:20 AM the next day.

ORD to DSM is the busiest airport pair, with 63 flights a week, then MDW to DSM with 12.

Flying back, Des Moines to Chicago has 72 nonstop flights a week.

Return flights

Des Moines to ChicagoView

Find the cheapest day to fly from Chicago to Des Moines.

Schedules as of Oct 9, 2026.