Nonstop flights from Des Moines to Chicago

3 airlines fly from Des Moines (DSM) to 2 Chicago airports (ORD and MDW), with up to 11 flights a day.

DSMORD

Routes

2 airport pairs

When they leave

Des Moines time

5:40a7:49pFirst departure 5:40 AM, last 7:49 PM

Nine in the morning, 5:40 AM to 11:32 AM, then seven in the afternoon, 12:10 PM to 3:50 PM, then two in the evening, 6:50 PM to 7:49 PM.

Every flight

Earliest first

5:40 AM→7:00 AMDSM to MDWSouthwest AirlinesBoeing 737 MAX 8Mon, Thu, Fri
6:00 AM→7:40 AMDSM to ORDUnited AirlinesAirbus A319Mon, Thu, Sat, Sun
6:00 AM→7:36 AMDSM to ORDUnited AirlinesAirbus A319Tue, Wed
6:10 AM→7:30 AMDSM to MDWSouthwest AirlinesBoeing 737-700Tue, Wed, Sat, Sun
6:55 AM→8:45 AMDSM to ORDAmerican AirlinesEmbraer 175Daily
7:35 AM→9:15 AMDSM to ORDUnited AirlinesBoeing 737 MAX 9Mon, Thu, Sat, Sun
8:00 AM→9:36 AMDSM to ORDUnited AirlinesAirbus A319Tue, Wed
10:26 AM→12:05 PMDSM to ORDAmerican AirlinesEmbraer 170Daily
11:23 AM→1:03 PMDSM to ORDUnited AirlinesBoeing 737Mon, Thu, Sat, Sun
11:32 AM→1:15 PMDSM to ORDUnited AirlinesBoeing 737Tue, Wed
12:10 PM→1:30 PMDSM to MDWSouthwest AirlinesBoeing 737 MAX 8Sat
1:21 PM→3:00 PMDSM to ORDUnited AirlinesEmbraer 175Tue, Wed
1:55 PM→3:41 PMDSM to ORDAmerican AirlinesCRJ 700Daily
2:40 PM→4:00 PMDSM to MDWSouthwest AirlinesBoeing 737 MAX 8Tue, Wed
3:20 PM→5:03 PMDSM to ORDUnited AirlinesBoeing 737Tue, Wed
3:24 PM→5:04 PMDSM to ORDUnited AirlinesCRJ 700Sat
3:24 PM→5:03 PMDSM to ORDUnited AirlinesBoeing 737Mon, Thu, Sun
3:50 PM→5:10 PMDSM to MDWSouthwest AirlinesBoeing 737Mon, Thu, Fri
3:50 PM→5:10 PMDSM to MDWSouthwest AirlinesBoeing 737-700Sun
6:50 PM→8:30 PMDSM to ORDUnited AirlinesEmbraer 175Mon, Thu, Sat, Sun
7:49 PM→9:37 PMDSM to ORDAmerican AirlinesCRJ 700Daily

Schedules last checked Sep 19, 2026. Times are local.

Flying from Des Moines to Chicago

United Airlines flies most often, 30 times a week on the Boeing 737, Airbus A319, Embraer 175, Boeing 737 MAX 9 and CRJ 700. American Airlines flies 4 times a day on the CRJ 700, Embraer 170 and Embraer 175. Southwest Airlines flies twice a day on the Boeing 737 MAX 8, Boeing 737-700 and Boeing 737.

Flights run every day of the week, from 6 on Fridays to 11 on Mondays, Tuesdays, Wednesdays, Thursdays, Saturdays and Sundays. The first arrival in Chicago is at 7:00 AM and the last at 9:37 PM.

DSM to ORD is the busiest airport pair, with 58 flights a week, then DSM to MDW with 14.

Flying back, Chicago to Des Moines has 75 nonstop flights a week.

Return flights

Chicago to Des MoinesView

Find the cheapest day to fly from Des Moines to Chicago.

Schedules as of Oct 9, 2026.