Nonstop flights from Des Moines to Chicago

2 airlines fly this route, with up to 9 flights a day.

DSMDes Moines International

298 mi · 58 flights a week

ORDChicago O'Hare International

DSMORD

When they leave

Des Moines time

6:00a7:49pFirst departure 6:00 AM, last 7:49 PM

Seven in the morning, 6:00 AM to 11:32 AM, then four in the afternoon, 1:21 PM to 3:24 PM, then two in the evening, 6:50 PM to 7:49 PM.

Every flight

Earliest first

6:00 AM→7:40 AMUnited AirlinesAirbus A319Mon, Thu, Sat, Sun
6:00 AM→7:36 AMUnited AirlinesAirbus A319Tue, Wed
6:55 AM→8:45 AMAmerican AirlinesEmbraer 175Daily
7:35 AM→9:15 AMUnited AirlinesBoeing 737 MAX 9Mon, Thu, Sat, Sun
8:00 AM→9:36 AMUnited AirlinesAirbus A319Tue, Wed
10:26 AM→12:05 PMAmerican AirlinesEmbraer 170Daily
11:23 AM→1:03 PMUnited AirlinesBoeing 737Mon, Thu, Sat, Sun
11:32 AM→1:15 PMUnited AirlinesBoeing 737Tue, Wed
1:21 PM→3:00 PMUnited AirlinesEmbraer 175Tue, Wed
1:55 PM→3:41 PMAmerican AirlinesCRJ 700Daily
3:20 PM→5:03 PMUnited AirlinesBoeing 737Tue, Wed
3:24 PM→5:04 PMUnited AirlinesCRJ 700Sat
3:24 PM→5:03 PMUnited AirlinesBoeing 737Mon, Thu, Sun
6:50 PM→8:30 PMUnited AirlinesEmbraer 175Mon, Thu, Sat, Sun
7:49 PM→9:37 PMAmerican AirlinesCRJ 700Daily

Schedules last checked Sep 19, 2026. Times are local.

Flying from Des Moines to Chicago

United Airlines flies most often, 30 times a week on the Boeing 737, Airbus A319, Embraer 175, Boeing 737 MAX 9 and CRJ 700. American Airlines flies 4 times a day on the CRJ 700, Embraer 170 and Embraer 175.

Flights run every day of the week, from 4 on Fridays to 9 on Mondays, Tuesdays, Wednesdays, Thursdays, Saturdays and Sundays. The first arrival in Chicago is at 7:36 AM and the last at 9:37 PM. The flight covers 298 miles.

Flying back, Chicago to Des Moines has 63 nonstop flights a week. From Des Moines, Midway (MDW) is the other Chicago area airport with nonstop flights, 14 a week.