Nonstop flights from Des Moines to Phoenix

2 airlines fly this route, with up to 4 flights a day.

DSMDes Moines International

1,148 mi · 21 flights a week · about 3h 9m

PHXPhoenix Sky Harbor International

DSMPHX

When they leave

Des Moines time

5:00a6:29pFirst departure 5:00 AM, last 6:29 PM

Two in the morning, 5:00 AM to 5:06 AM, then four in the afternoon, 1:50 PM to 2:40 PM, then two in the evening, 6:02 PM to 6:29 PM.

Every flight

Earliest first

5:00 AM→7:09 AMAmerican AirlinesAirbus A319 · 3h 9mMon, Sun
5:06 AM→6:12 AMAmerican AirlinesAirbus A319 · 3h 6mTue, Wed, Thu, Fri, Sat
1:50 PM→3:50 PMSouthwest AirlinesUntil Jun 2, 2027Boeing 737 · 3hMon, Sun
2:00 PM→3:05 PMSouthwest AirlinesUntil Jun 2, 2027Boeing 737 · 3h 5mThu, Fri
2:30 PM→3:33 PMAmerican AirlinesAirbus A319 · 3h 4mTue, Wed, Thu, Fri, Sat
2:40 PM→4:49 PMAmerican AirlinesAirbus A319 · 3h 9mMon, Sun
6:02 PM→8:33 PMAmerican AirlinesEmbraer 175 · 3h 31mSun
6:29 PM→7:55 PMAmerican AirlinesEmbraer 175 · 3h 26mThu, Fri

Schedules last checked Oct 7, 2026. Times are local.

Flying from Des Moines to Phoenix

American Airlines flies most often, 2 to 3 times a day on the Airbus A319 and Embraer 175. Southwest Airlines flies 4 times a week on the Boeing 737.

Flights run every day of the week, from 2 on Tuesdays, Wednesdays and Saturdays to 4 on Thursdays, Fridays and Sundays. The first arrival in Phoenix is at 6:12 AM and the last at 8:33 PM. The flight covers 1,148 miles, and scheduled flight times run from 3h to 3h 31m.

Southwest Airlines flies it until Jun 2, 2027.

Flying back, Phoenix to Des Moines has 14 nonstop flights a week.

Return flights

Phoenix to Des MoinesView

Find the cheapest day to fly from Des Moines to Phoenix.

Schedules as of Oct 9, 2026.