Nonstop flights from Des Moines to Charlotte
American Airlines flies this route 2 to 3 times a day.
DSMDes Moines International
814 mi · 19 flights a week
CLTCharlotte Douglas International
When they leave
Des Moines time8:10a5:10pFirst departure 8:10 AM, last 5:10 PM
One morning flight at 8:10 AM, then one afternoon flight at 1:08 PM, then one evening flight at 5:10 PM.
Every flight
Earliest first
Schedules last checked Sep 8, 2026. Times are local.
Flying from Des Moines to Charlotte
American Airlines is the only airline flying nonstop from Des Moines to Charlotte, 2 to 3 times a day on the Airbus A319 and CRJ 900.
There are 2 or 3 flights every day of the week. The first arrival in Charlotte is at 11:32 AM and the last at 8:48 PM. The flight covers 814 miles.
Flying back, Charlotte to Des Moines has 20 nonstop flights a week.
Return flights
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Find the cheapest day to fly from Des Moines to Charlotte.
Schedules as of Oct 9, 2026.