Nonstop flights from Detroit to Des Moines
Delta Air Lines flies this route 3 times a day.
DTWDetroit Metropolitan Wayne County
531 mi · 21 flights a week
DSMDes Moines International
When they leave
Detroit time8:45a7:45pFirst departure 8:45 AM, last 7:45 PM
One morning flight at 8:45 AM, then one afternoon flight at 4:18 PM, then one evening flight at 7:45 PM. Every flight runs daily.
Every flight
Earliest first
Schedules last checked Sep 20, 2026. Times are local.
Flying from Detroit to Des Moines
Delta Air Lines is the only airline flying nonstop from Detroit to Des Moines, 3 times a day on the CRJ 700 and CRJ 900.
The first arrival in Des Moines is at 9:43 AM and the last at 8:39 PM. The flight covers 531 miles.
Flying back, Des Moines to Detroit has 21 nonstop flights a week.
Return flights
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Schedules as of Oct 9, 2026.