Nonstop flights from Chicago to St. Louis

Southwest Airlines flies this route 3 to 5 times a day.

MDWChicago Midway International

252 mi · 33 flights a week

STLSt. Louis Lambert International

MDWSTL

When they leave

Chicago time

7:55a8:55pFirst departure 7:55 AM, last 8:55 PM

Four in the morning, 7:55 AM to 10:10 AM, then three in the afternoon, 2:00 PM to 4:40 PM, then three in the evening, 5:50 PM to 8:55 PM.

Every flight

Earliest first

7:55 AM→9:15 AMSouthwest AirlinesBoeing 737-700Daily
9:20 AM→10:30 AMSouthwest AirlinesBoeing 737-700Mon, Thu, Fri, Sun
9:55 AM→11:05 AMSouthwest AirlinesBoeing 737-700Sat
10:10 AM→11:20 AMSouthwest AirlinesBoeing 737-700Tue, Wed
2:00 PM→3:10 PMSouthwest AirlinesBoeing 737 MAX 8Tue, Wed
3:10 PM→4:20 PMSouthwest AirlinesBoeing 737-700Mon, Thu, Fri, Sun
4:40 PM→5:55 PMSouthwest AirlinesBoeing 737 MAX 8Tue, Wed, Sat
5:50 PM→7:05 PMSouthwest AirlinesBoeing 737-700Mon, Tue, Wed, Thu, Fri, Sun
8:25 PM→9:35 PMSouthwest AirlinesBoeing 737Sun
8:55 PM→10:05 PMSouthwest AirlinesBoeing 737 MAX 8Mon, Thu, Fri

Schedules last checked Sep 20, 2026. Times are local.

Flying from Chicago to St. Louis

Southwest Airlines is the only airline flying nonstop from Chicago to St. Louis, 3 to 5 times a day on the Boeing 737-700, Boeing 737 MAX 8 and Boeing 737.

Flights run every day of the week, from 3 on Saturdays to 5 on Mondays, Tuesdays, Wednesdays, Thursdays, Fridays and Sundays. The first arrival in St. Louis is at 9:15 AM and the last at 10:05 PM. The flight covers 252 miles.

Flying back, St. Louis to Chicago has 33 nonstop flights a week. O'Hare (ORD) also has nonstop flights to St. Louis, 102 a week.