Nonstop flights from St. Louis to Chicago

Southwest Airlines flies this route 3 to 5 times a day.

STLSt. Louis Lambert International

252 mi · 33 flights a week

MDWChicago Midway International

STLMDW

When they leave

St. Louis time

6:00a8:50pFirst departure 6:00 AM, last 8:50 PM

Four in the morning, 6:00 AM to 11:05 AM, then three in the afternoon, 2:20 PM to 3:45 PM, then three in the evening, 6:15 PM to 8:50 PM.

Every flight

Earliest first

6:00 AM→7:05 AMSouthwest AirlinesBoeing 737 MAX 8Sun
6:05 AM→7:10 AMSouthwest AirlinesBoeing 737-700Daily
8:50 AM→9:55 AMSouthwest AirlinesBoeing 737 MAX 8Sun
11:05 AM→12:15 PMSouthwest AirlinesBoeing 737-700Mon, Tue, Wed, Thu, Fri, Sat
2:20 PM→3:25 PMSouthwest AirlinesBoeing 737Mon, Tue, Wed, Thu, Fri, Sat
3:30 PM→4:35 PMSouthwest AirlinesBoeing 737Sun
3:45 PM→4:50 PMSouthwest AirlinesBoeing 737 MAX 8Tue, Wed
6:15 PM→7:20 PMSouthwest AirlinesBoeing 737-700Mon, Thu, Fri
7:30 PM→8:35 PMSouthwest AirlinesBoeing 737 MAX 8Sun
8:50 PM→9:55 PMSouthwest AirlinesBoeing 737 MAX 8Mon, Tue, Wed, Thu, Fri

Schedules last checked Sep 19, 2026. Times are local.

Flying from St. Louis to Chicago

Southwest Airlines is the only airline flying nonstop from St. Louis to Chicago, 3 to 5 times a day on the Boeing 737 MAX 8, Boeing 737-700 and Boeing 737.

Flights run every day of the week, from 3 on Saturdays to 5 on Mondays, Tuesdays, Wednesdays, Thursdays, Fridays and Sundays. The first arrival in Chicago is at 7:05 AM and the last at 9:55 PM. The flight covers 252 miles.

Flying back, Chicago to St. Louis has 33 nonstop flights a week. From St. Louis, O'Hare (ORD) is the other Chicago area airport with nonstop flights, 102 a week.