Nonstop flights from St. Louis to Detroit
2 airlines fly this route, with up to 6 flights a day.
STLSt. Louis Lambert International
439 mi · 41 flights a week
DTWDetroit Metropolitan Wayne County
When they leave
St. Louis time6:30a7:55pFirst departure 6:30 AM, last 7:55 PM
Six in the morning, 6:30 AM to 11:10 AM, then one afternoon flight at 2:10 PM, then four in the evening, 6:25 PM to 7:55 PM.
Every flight
Earliest first
Schedules last checked Sep 19, 2026. Times are local.
Flying from St. Louis to Detroit
Delta Air Lines flies most often, 3 to 4 times a day on the Boeing 717. Southwest Airlines flies twice a day on the Boeing 737-700 and Boeing 737.
There are 5 or 6 flights every day of the week. The first arrival in Detroit is at 9:04 AM and the last at 10:30 PM. The flight covers 439 miles.
Flying back, Detroit to St. Louis has 41 nonstop flights a week.
Return flights
More from St. Louis
Find the cheapest day to fly from St. Louis to Detroit.
Schedules as of Oct 9, 2026.