Nonstop flights from Detroit to St. Louis

2 airlines fly this route, with up to 6 flights a day.

DTWDetroit Metropolitan Wayne County

439 mi · 41 flights a week

STLSt. Louis Lambert International

DTWSTL

When they leave

Detroit time

6:25a8:05pFirst departure 6:25 AM, last 8:05 PM

Four in the morning, 6:25 AM to 9:00 AM, then four in the afternoon, 12:36 PM to 4:59 PM, then two in the evening, 7:50 PM to 8:05 PM.

Every flight

Earliest first

6:25 AM→7:00 AMSouthwest AirlinesBoeing 737-700Tue, Wed
6:35 AM→7:10 AMSouthwest AirlinesBoeing 737 MAX 8Sat, Sun
6:55 AM→7:45 AMSouthwest AirlinesBoeing 737-700Mon, Thu, Fri
9:00 AM→9:37 AMDelta Air LinesBoeing 717Daily
12:36 PM→1:14 PMDelta Air LinesBoeing 717Mon, Tue, Wed, Thu, Fri, Sun
2:40 PM→3:10 PMSouthwest AirlinesBoeing 737-700Mon, Thu, Fri, Sat
3:35 PM→4:10 PMSouthwest AirlinesBoeing 737-700Tue, Wed
4:59 PM→5:38 PMDelta Air LinesBoeing 717Daily
7:50 PM→8:20 PMSouthwest AirlinesBoeing 737Sun
8:05 PM→8:42 PMDelta Air LinesBoeing 717Daily

Schedules last checked Sep 19, 2026. Times are local.

Flying from Detroit to St. Louis

Delta Air Lines flies most often, 3 to 4 times a day on the Boeing 717. Southwest Airlines flies twice a day on the Boeing 737-700, Boeing 737 and Boeing 737 MAX 8.

There are 5 or 6 flights every day of the week. The first arrival in St. Louis is at 7:00 AM and the last at 8:42 PM. The flight covers 439 miles.

Flying back, St. Louis to Detroit has 41 nonstop flights a week.

Return flights

St. Louis to DetroitView

Find the cheapest day to fly from Detroit to St. Louis.

Schedules as of Oct 9, 2026.