Nonstop flights from Pittsburgh to St. Louis
Southwest Airlines flies this route 1 to 2 times a day.
PITPittsburgh International
551 mi · 13 flights a week
STLSt. Louis Lambert International
When they leave
Pittsburgh time6:40a7:20pFirst departure 6:40 AM, last 7:20 PM
Two in the morning, 6:40 AM to 7:00 AM, then one evening flight at 7:20 PM.
Every flight
Earliest first
Schedules last checked Sep 20, 2026. Times are local.
Flying from Pittsburgh to St. Louis
Southwest Airlines is the only airline flying nonstop from Pittsburgh to St. Louis, 1 to 2 times a day on the Boeing 737-700 and Boeing 737 MAX 8.
There are 1 or 2 flights every day of the week. The first arrival in St. Louis is at 7:20 AM and the last at 8:00 PM. The flight covers 551 miles.
Flying back, St. Louis to Pittsburgh has 13 nonstop flights a week.
Return flights
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Schedules as of Oct 9, 2026.