Nonstop flights from St. Louis to Pittsburgh
Southwest Airlines flies this route 1 to 2 times a day.
STLSt. Louis Lambert International
551 mi · 13 flights a week
PITPittsburgh International
When they leave
St. Louis time10:30a7:35pFirst departure 10:30 AM, last 7:35 PM
One morning flight at 10:30 AM, then one evening flight at 7:35 PM.
Every flight
Earliest first
Schedules last checked Sep 19, 2026. Times are local.
Flying from St. Louis to Pittsburgh
Southwest Airlines is the only airline flying nonstop from St. Louis to Pittsburgh, 1 to 2 times a day on the Boeing 737 MAX 8 and Boeing 737-700.
There are 1 or 2 flights every day of the week. The first arrival in Pittsburgh is at 1:10 PM and the last at 10:15 PM. The flight covers 551 miles.
Flying back, Pittsburgh to St. Louis has 13 nonstop flights a week.
Return flights
More from St. Louis
Find the cheapest day to fly from St. Louis to Pittsburgh.
Schedules as of Oct 9, 2026.