Nonstop flights from Houston to Knoxville
United Airlines flies this route 2 to 3 times a day.
IAHHouston George Bush Intercontinental
771 mi · 19 flights a week
TYSKnoxville McGhee Tyson
When they leave
Houston time10:00a6:25pFirst departure 10:00 AM, last 6:25 PM
One morning flight at 10:00 AM, then one afternoon flight at 2:57 PM, then one evening flight at 6:25 PM.
Every flight
Earliest first
Schedules last checked Sep 20, 2026. Times are local.
Flying from Houston to Knoxville
United Airlines is the only airline flying nonstop from Houston to Knoxville, 2 to 3 times a day on the Embraer 175.
There are 2 or 3 flights every day of the week. The first arrival in Knoxville is at 1:20 PM and the last at 9:45 PM. The flight covers 771 miles.
Flying back, Knoxville to Houston has 21 nonstop flights a week.
Return flights
Every Houston airport
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Find the cheapest day to fly from Houston to Knoxville.
Schedules as of Oct 9, 2026.