Nonstop flights from Detroit to Knoxville
Delta Air Lines flies this route 2 to 3 times a day.
DTWDetroit Metropolitan Wayne County
444 mi · 20 flights a week
TYSKnoxville McGhee Tyson
When they leave
Detroit time8:40a7:55pFirst departure 8:40 AM, last 7:55 PM
One morning flight at 8:40 AM, then one afternoon flight at 4:00 PM, then one evening flight at 7:55 PM.
Every flight
Earliest first
Schedules last checked Sep 21, 2026. Times are local.
Flying from Detroit to Knoxville
Delta Air Lines is the only airline flying nonstop from Detroit to Knoxville, 2 to 3 times a day on the CRJ 700 and CRJ 900.
There are 2 or 3 flights every day of the week. The first arrival in Knoxville is at 10:20 AM and the last at 9:34 PM. The flight covers 444 miles.
Flying back, Knoxville to Detroit has 20 nonstop flights a week.
Return flights
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Find the cheapest day to fly from Detroit to Knoxville.
Schedules as of Oct 9, 2026.