Nonstop flights from Knoxville to Detroit
Delta Air Lines flies this route 2 to 3 times a day.
TYSKnoxville McGhee Tyson
444 mi · 20 flights a week
DTWDetroit Metropolitan Wayne County
When they leave
Knoxville time7:15a5:22pFirst departure 7:15 AM, last 5:22 PM
Two in the morning, 7:15 AM to 11:38 AM, then one evening flight at 5:22 PM.
Every flight
Earliest first
Schedules last checked Sep 21, 2026. Times are local.
Flying from Knoxville to Detroit
Delta Air Lines is the only airline flying nonstop from Knoxville to Detroit, 2 to 3 times a day on the CRJ 700 and CRJ 900.
There are 2 or 3 flights every day of the week. The first arrival in Detroit is at 9:01 AM and the last at 7:08 PM. The flight covers 444 miles.
Flying back, Detroit to Knoxville has 20 nonstop flights a week.
Return flights
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Find the cheapest day to fly from Knoxville to Detroit.
Schedules as of Oct 9, 2026.