Nonstop flights from Houston to Knoxville

2 airlines fly from 2 Houston airports (IAH and HOU) to Knoxville (TYS), with up to 4 flights a day.

IAHTYS

Routes

2 airport pairs

IAH to TYSGeorge Bush Intercontinental to McGhee Tyson2 to 3 a day
HOU to TYSWilliam P. Hobby to McGhee Tyson5 a week

When they leave

Houston time

10:00a7:52pFirst departure 10:00 AM, last 7:52 PM

One morning flight at 10:00 AM, then two in the afternoon, 2:57 PM to 3:36 PM, then three in the evening, 5:06 PM to 7:52 PM.

Every flight

Earliest first

10:00 AM→1:20 PMIAH to TYSUnited AirlinesEmbraer 175Daily
2:57 PM→6:17 PMIAH to TYSUnited AirlinesEmbraer 175Daily
3:36 PM→6:43 PMHOU to TYSAllegiant AirUntil Nov 29, back Dec 19Airbus A320Fri
5:06 PM→8:06 PMHOU to TYSAllegiant AirUntil Nov 29, back Dec 19Airbus A320Sat
6:25 PM→9:45 PMIAH to TYSUnited AirlinesEmbraer 175Mon, Tue, Wed, Thu, Sun
7:52 PM→10:54 PMHOU to TYSAllegiant AirUntil Nov 29, back Dec 19Airbus A320Sun
7:52 PM→10:54 PMHOU to TYSAllegiant AirUntil Nov 29, back Dec 19Airbus A320Mon, Wed

Schedules last checked Sep 21, 2026. Times are local.

Flying from Houston to Knoxville

United Airlines flies most often, 2 to 3 times a day on the Embraer 175. Allegiant Air flies 5 times a week on the Airbus A320.

Flights run every day of the week, 4 on Mondays, Wednesdays and Sundays and 3 on the other days. The first arrival in Knoxville is at 1:20 PM and the last at 10:54 PM.

IAH to TYS is the busiest airport pair, with 19 flights a week, then HOU to TYS with 5.

On HOU to TYS, Allegiant Air flies it until Nov 29 and is back on Dec 19.

Flying back, Knoxville to Houston has 26 nonstop flights a week.

Return flights

Knoxville to HoustonView

Find the cheapest day to fly from Houston to Knoxville.

Schedules as of Oct 9, 2026.