Nonstop flights from Cleveland to St. Louis
Southwest Airlines flies this route twice a day.
CLECleveland Hopkins International
487 mi · 14 flights a week
STLSt. Louis Lambert International
When they leave
Cleveland time7:20a7:20pFirst departure 7:20 AM, last 7:20 PM
One morning flight at 7:20 AM, then one afternoon flight at 12:50 PM, then one evening flight at 7:20 PM.
Every flight
Earliest first
Schedules last checked Sep 8, 2026. Times are local.
Flying from Cleveland to St. Louis
Southwest Airlines is the only airline flying nonstop from Cleveland to St. Louis, twice a day on the Boeing 737-700 and Boeing 737.
The first arrival in St. Louis is at 7:50 AM and the last at 7:55 PM. The flight covers 487 miles.
Flying back, St. Louis to Cleveland has 14 nonstop flights a week.
Return flights
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Schedules as of Oct 9, 2026.