Nonstop flights from Columbus to St. Louis
Southwest Airlines flies this route 1 to 2 times a day.
CMHJohn Glenn Columbus International
409 mi · 13 flights a week
STLSt. Louis Lambert International
When they leave
Columbus time6:40a7:35pFirst departure 6:40 AM, last 7:35 PM
Two in the morning, 6:40 AM to 7:20 AM, then two in the evening, 7:25 PM to 7:35 PM.
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Earliest first
Schedules last checked Sep 19, 2026. Times are local.
Flying from Columbus to St. Louis
Southwest Airlines is the only airline flying nonstop from Columbus to St. Louis, 1 to 2 times a day on the Boeing 737 MAX 8 and Boeing 737.
There are 1 or 2 flights every day of the week. The first arrival in St. Louis is at 7:05 AM and the last at 8:00 PM. The flight covers 409 miles.
Flying back, St. Louis to Columbus has 11 nonstop flights a week.
Return flights
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Schedules as of Oct 9, 2026.