Nonstop flights from Santiago to La Serena
3 airlines fly this route, with up to 9 flights a day.
SCLSantiago Arturo Merino Benitez International
242 mi · 48 flights a week
LSCLa Serena La Florida
When they leave
Santiago time6:00a8:38pFirst departure 6:00 AM, last 8:38 PM
Seven in the morning, 6:00 AM to 11:37 AM, then nine in the afternoon, 1:20 PM to 4:15 PM, then three in the evening, 5:20 PM to 8:38 PM.
Every flight
Earliest first
Schedules last checked Sep 19, 2026. Times are local.
Flying from Santiago to La Serena
LATAM Airlines Chile flies most often, 3 to 5 times a day on the Airbus A320 and Airbus A321. SKY Airline flies 1 to 3 times a day on the Airbus A320neo and Airbus A321neo. JetSMART flies 5 times a week on the Airbus A321 and Airbus A320.
Flights run every day of the week, from 5 on Saturdays to 9 on Wednesdays. The first arrival in La Serena is at 7:11 AM and the last at 9:47 PM. The flight covers 242 miles.
Flying back, La Serena to Santiago has 50 nonstop flights a week.
Return flights
Find the cheapest day to fly from Santiago to La Serena.
Schedules as of Oct 9, 2026.