Nonstop flights from St. Louis to Jacksonville

Southwest Airlines flies this route 1 to 2 times a day.

STLSt. Louis Lambert International

753 mi · 9 flights a week

JAXJacksonville International

STLJAX

When they leave

St. Louis time

8:35a6:55pFirst departure 8:35 AM, last 6:55 PM

Two in the morning, 8:35 AM to 10:20 AM, then one afternoon flight at 2:05 PM, then one evening flight at 6:55 PM.

Every flight

Earliest first

8:35 AM→11:35 AMSouthwest AirlinesBoeing 737 MAX 8Sat
10:20 AM→1:20 PMSouthwest AirlinesBoeing 737-700Tue, Wed, Sat, Sun
2:05 PM→5:05 PMSouthwest AirlinesBoeing 737 MAX 8Mon, Thu, Fri
6:55 PM→9:55 PMSouthwest AirlinesBoeing 737Sun

Schedules last checked Sep 19, 2026. Times are local.

Flying from St. Louis to Jacksonville

Southwest Airlines is the only airline flying nonstop from St. Louis to Jacksonville, 1 to 2 times a day on the Boeing 737 MAX 8, Boeing 737 and Boeing 737-700.

Flights run every day of the week, 2 on Saturdays and Sundays and 1 on the other days. The first arrival in Jacksonville is at 11:35 AM and the last at 9:55 PM. The flight covers 753 miles.

Flying back, Jacksonville to St. Louis has 9 nonstop flights a week.

Return flights

Jacksonville to St. LouisView

Find the cheapest day to fly from St. Louis to Jacksonville.

Schedules as of Oct 9, 2026.