Nonstop flights from San Francisco to Panama City
Copa Airlines flies this route 1 to 2 times a day.
SFOSan Francisco International
3,321 mi · 11 flights a week
PTYPanama City Tocumen International Airport Panama
When they leave
San Francisco time1:12a8:21pFirst departure 1:12 AM, last 8:21 PM
One overnight flight at 1:12 AM, then one evening flight at 8:21 PM.
Every flight
Earliest first
Schedules last checked Sep 19, 2026. Times are local.
Flying from San Francisco to Panama City
Copa Airlines is the only airline flying nonstop from San Francisco to Panama City, 1 to 2 times a day on the Boeing 737 MAX 9.
There are 1 or 2 flights every day of the week. The first arrival in Panama City is at 10:27 AM and the last at 5:35 AM the next day. The flight covers 3,321 miles.
Flying back, Panama City to San Francisco has 10 nonstop flights a week.
Return flights
More from San Francisco
Find the cheapest day to fly from San Francisco to Panama City.
Schedules as of Oct 9, 2026.