Nonstop flights from Greenville to Chicago
2 airlines fly this route, with up to 7 flights a day.
GSPGreenville-Spartanburg International
578 mi · 49 flights a week
ORDChicago O'Hare International
When they leave
Greenville time6:30a6:34pFirst departure 6:30 AM, last 6:34 PM
Five in the morning, 6:30 AM to 11:31 AM, then three in the afternoon, 2:18 PM to 2:28 PM, then two in the evening, 5:43 PM to 6:34 PM.
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Earliest first
Schedules last checked Sep 8, 2026. Times are local.
Flying from Greenville to Chicago
United Airlines flies most often, 4 times a day on the Embraer 175, Boeing 737 and CRJ 700. American Airlines flies 3 times a day on the Embraer 175.
There are 7 flights every day of the week. The first arrival in Chicago is at 7:47 AM and the last at 8:04 PM. The flight covers 578 miles.
Flying back, Chicago to Greenville has 49 nonstop flights a week.
Return flights
More from Greenville
Find the cheapest day to fly from Greenville to Chicago.
Schedules as of Oct 9, 2026.