Nonstop flights from Greenville to Detroit
Delta Air Lines flies this route 2 to 3 times a day.
GSPGreenville-Spartanburg International
510 mi · 20 flights a week
DTWDetroit Metropolitan Wayne County
When they leave
Greenville time7:15a6:58pFirst departure 7:15 AM, last 6:58 PM
Two in the morning, 7:15 AM to 11:10 AM, then one afternoon flight at 12:39 PM, then one evening flight at 6:58 PM.
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Earliest first
Schedules last checked Sep 19, 2026. Times are local.
Flying from Greenville to Detroit
Delta Air Lines is the only airline flying nonstop from Greenville to Detroit, 2 to 3 times a day on the Boeing 717, CRJ 700 and CRJ 900.
There are 2 or 3 flights every day of the week. The first arrival in Detroit is at 9:02 AM and the last at 8:49 PM. The flight covers 510 miles.
Flying back, Detroit to Greenville has 20 nonstop flights a week.
Return flights
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Schedules as of Oct 9, 2026.