Nonstop flights from Chicago to Knoxville

3 airlines fly from 2 Chicago airports (ORD and MDW) to Knoxville (TYS), with up to 9 flights a day.

ORDTYS

Routes

2 airport pairs

ORD to TYSChicago O'Hare to McGhee Tyson8 a day
MDW to TYSChicago Midway to McGhee Tyson4 a week

When they leave

Chicago time

6:59a7:29pFirst departure 6:59 AM, last 7:29 PM

Four in the morning, 6:59 AM to 10:29 AM, then five in the afternoon, 12:56 PM to 3:30 PM, then two in the evening, 6:06 PM to 7:29 PM.

Every flight

Earliest first

6:59 AM→9:57 AMORD to TYSUnited AirlinesCRJ 700Mon, Thu, Fri
6:59 AM→9:57 AMORD to TYSUnited AirlinesCRJ 700Tue, Wed, Sat, Sun
8:18 AM→11:10 AMORD to TYSAmerican AirlinesCRJ 700Daily
10:05 AM→12:51 PMORD to TYSAmerican AirlinesEmbraer 170Daily
10:29 AM→1:17 PMORD to TYSUnited AirlinesCRJ 700Daily
12:56 PM→3:21 PMMDW to TYSAllegiant AirUntil Nov 29Airbus A320Mon
2:10 PM→4:58 PMORD to TYSUnited AirlinesAirbus A319Daily
2:24 PM→4:49 PMMDW to TYSAllegiant AirUntil Nov 29Airbus A320Fri
3:27 PM→5:54 PMMDW to TYSAllegiant AirUntil Nov 29Airbus A320Sun
3:27 PM→5:54 PMMDW to TYSAllegiant AirUntil Nov 29Airbus A320Wed
3:30 PM→6:22 PMORD to TYSAmerican AirlinesCRJ 700Daily
6:06 PM→8:53 PMORD to TYSUnited AirlinesBoeing 737Daily
7:29 PM→10:17 PMORD to TYSAmerican AirlinesEmbraer 170Daily

Schedules last checked Sep 22, 2026. Times are local.

Flying from Chicago to Knoxville

American Airlines flies 4 times a day on the CRJ 700 and Embraer 170. United Airlines flies 4 times a day on the CRJ 700, Airbus A319 and Boeing 737. Allegiant Air flies 4 times a week on the Airbus A320.

There are 8 or 9 flights every day of the week. The first arrival in Knoxville is at 9:57 AM and the last at 10:17 PM.

ORD to TYS is the busiest airport pair, with 56 flights a week, then MDW to TYS with 4.

On MDW to TYS, Allegiant Air flies it until Nov 29.

Flying back, Knoxville to Chicago has 60 nonstop flights a week.

Return flights

Knoxville to ChicagoView

Find the cheapest day to fly from Chicago to Knoxville.

Schedules as of Oct 9, 2026.